{"entity":{"id":"plcg1","kind":"target","name":"PLCG1","aka":["phospholipase C gamma 1","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1","PLC148","PLC-II","PLCgamma1","NCKAP3","PLC1"],"tldr":"PLCG1 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Renal cell carcinoma, Non-Hodgkin lymphoma and 5 more.","summary":"Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signalling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.97, genetic association 0.17, somatic mutation 0.91). IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Angiosarcoma, Low-Grade Glioma, NOS, Renal Cell Carcinoma, Soft Tissue.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9065","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9065"},{"label":"UniProt P19174","url":"https://www.uniprot.org/uniprotkb/P19174/entry"},{"label":"NCBI Gene 5335","url":"https://www.ncbi.nlm.nih.gov/gene/5335"},{"label":"Ensembl ENSG00000124181","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124181"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["sarcoma","rcc","non-hodgkin-lymphoma","skin-cancer","leukaemia","gastric","angiosarcoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Adult T-cell Leukaemia/lymphoma; Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PLCG1","role":["oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9065","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9065","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P19174","url":"https://www.uniprot.org/uniprotkb/P19174/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PLCG1","url":"https://civicdb.org/features/4326","note":"1 evidence items, 0 assertions, 1 variants; diseases: Adult T-cell Leukaemia/lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000124181","url":"https://platform.opentargets.org/target/ENSG00000124181/associations","note":"association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: gastric cancer 0.50, melanoma 0.52, sarcoma 0.58, non-Hodgkin lymphoma 0.56, skin cancer 0.55, leukaemia 0.52 (GraphQL API, CC0)"},{"label":"IntOGen PLCG1","url":"https://www.intogen.org/search?gene=PLCG1","note":"driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9065","ensembl":"ENSG00000124181","uniprot":"P19174","entrez":"5335","biology":"Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signalling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganisation and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyses the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. Location: Cell projection, lamellipodium; Cell projection, ruffle (UniProt). Locus 20q12 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089); IntOGen driver in 1 cohort (SOFT_TISSUE)","Renal cell carcinoma: IntOGen driver in 1 cohort (RCC)","Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/plcg1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"angiosarcoma","kind":"cancer","name":"Angiosarcoma","route":"/cancers/angiosarcoma/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}