{"entity":{"id":"plxnb2","kind":"target","name":"PLXNB2","aka":["plexin B2","Plexin-B2","MM1","KIAA0315","PLEXB2","lncFAL"],"tldr":"PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.93, animal model 0.55, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9104","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9104"},{"label":"UniProt O15031","url":"https://www.uniprot.org/uniprotkb/O15031/entry"},{"label":"NCBI Gene 23654","url":"https://www.ncbi.nlm.nih.gov/gene/23654"},{"label":"Ensembl ENSG00000196576","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196576"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PLXNB2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9104","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9104","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15031","url":"https://www.uniprot.org/uniprotkb/O15031/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196576","url":"https://platform.opentargets.org/target/ENSG00000196576/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9104","ensembl":"ENSG00000196576","uniprot":"O15031","entrez":"23654","biology":"Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Location: Cell membrane (UniProt). Locus 22q13.33 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/plxnb2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}