{"entity":{"id":"plxnc1","kind":"target","name":"PLXNC1","aka":["plexin C1","Plexin-C1","VESPR","CD232"],"tldr":"PLXNC1 (Plexin-C1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.","summary":"Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9106","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9106"},{"label":"UniProt O60486","url":"https://www.uniprot.org/uniprotkb/O60486/entry"},{"label":"NCBI Gene 10154","url":"https://www.ncbi.nlm.nih.gov/gene/10154"},{"label":"Ensembl ENSG00000136040","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136040"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PLXNC1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9106","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9106","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60486","url":"https://www.uniprot.org/uniprotkb/O60486/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PLXNC1","url":"https://www.intogen.org/search?gene=PLXNC1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9106","ensembl":"ENSG00000136040","uniprot":"O60486","entrez":"10154","biology":"Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Location: Membrane (UniProt). Locus 12q22 (HGNC).","whereFound":["Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/plxnc1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}