{"entity":{"id":"pms1","kind":"target","name":"PMS1","aka":["PMS1 homolog 1, mismatch repair system component","PMS1 protein homolog 1","MLH2","PMSL1"],"tldr":"PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Probably involved in the repair of mismatches in DNA.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.38, genetic association 0.76, somatic mutation 0.50, genetic literature 0.01).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9121","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9121"},{"label":"UniProt P54277","url":"https://www.uniprot.org/uniprotkb/P54277/entry"},{"label":"NCBI Gene 5378","url":"https://www.ncbi.nlm.nih.gov/gene/5378"},{"label":"Ensembl ENSG00000064933","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000064933"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PMS1","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9121","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9121","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P54277","url":"https://www.uniprot.org/uniprotkb/P54277/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000064933","url":"https://platform.opentargets.org/target/ENSG00000064933/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:9121","ensembl":"ENSG00000064933","uniprot":"P54277","entrez":"5378","biology":"Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 2q32.2 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)"],"targetClass":"other","prevalence":[]},"route":"/targets/pms1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}