{"entity":{"id":"pnmt","kind":"target","name":"PNMT","aka":["phenylethanolamine N-methyltransferase","PENT"],"tldr":"PNMT makes adrenaline from noradrenaline in the adrenal gland; in breast cancer it matters only because it lies inside the HER2 amplicon.","summary":"17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes PNMT as the enzyme that converts noradrenaline to adrenaline; its expression in HER2-positive tumours reflects gene dosage, not adrenal biology.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:9160","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9160"},{"label":"UniProt P11086","url":"https://www.uniprot.org/uniprotkb/P11086/entry"}],"tags":["cansim-terms"],"related":["her2"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["co-amplification","cancer-ai-vocabulary"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"PNMT","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9160","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9160","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt P11086","url":"https://www.uniprot.org/uniprotkb/P11086/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:9160","ensembl":"ENSG00000141744","uniprot":"P11086","entrez":"5409","biology":"Catalyses the transmethylation of noradrenaline to adrenaline using S-adenosyl-L-methionine (UniProt P11086).","whereFound":["Locus 17q12 (HGNC)."],"targetClass":"enzyme","prevalence":[]},"route":"/targets/pnmt/","neighbours":{"target":[{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"}]}}