{"entity":{"id":"poglut3","kind":"target","name":"POGLUT3","aka":["protein O-glucosyltransferase 3","Protein O-glucosyltransferase 3","MGC33424","KDELC2"],"tldr":"POGLUT3 (Protein O-glucosyltransferase 3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Protein glucosyltransferase that catalyses the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyse the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.71).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28496","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28496"},{"label":"UniProt Q7Z4H8","url":"https://www.uniprot.org/uniprotkb/Q7Z4H8/entry"},{"label":"NCBI Gene 143888","url":"https://www.ncbi.nlm.nih.gov/gene/143888"},{"label":"Ensembl ENSG00000178202","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178202"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"POGLUT3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28496","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28496","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z4H8","url":"https://www.uniprot.org/uniprotkb/Q7Z4H8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000178202","url":"https://platform.opentargets.org/target/ENSG00000178202/associations","note":"association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:28496","ensembl":"ENSG00000178202","uniprot":"Q7Z4H8","entrez":"143888","biology":"Protein glucosyltransferase that catalyses the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyse the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signalling pathway. Location: Endoplasmic reticulum lumen (UniProt). Locus 11q22.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/poglut3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}