{"entity":{"id":"polaris-group","kind":"company","name":"Polaris Group","aka":["Polaris Pharmaceuticals","Polaris Pharmaceuticals, Inc."],"tldr":"Polaris Group develops pegargiminase (ADI-PEG 20), an enzyme that starves tumours lacking argininosuccinate synthetase of arginine, which improved survival in pleural mesothelioma in the phase 3 ATOMIC-Meso trial.","summary":"Polaris Group, based in San Diego with roots in Taiwan, develops ADI-PEG 20 (pegargiminase), a pegylated arginine deiminase that removes arginine from the blood. Tumours that have lost the enzyme argininosuccinate synthetase 1 (ASS1) cannot make their own arginine and are selectively starved; the approach was tested in liver cancer, melanoma and sarcoma before the phase 3 ATOMIC-Meso trial in non-epithelioid pleural mesothelioma reported longer survival with pegargiminase added to chemotherapy. It appears on OnCo as a lead sponsor of phase 3 cancer trials on ClinicalTrials.gov.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://www.polarispharma.com"},{"label":"ClinicalTrials.gov: trials led by Polaris Group","url":"https://clinicaltrials.gov/search?lead=Polaris%20Group"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["mesothelioma","hcc"],"sections":["targeted-therapy"],"technologies":[],"targets":[],"drugs":["adi-peg20"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"San Diego, CA","country":"US","companyType":"biotech","website":"https://www.polarispharma.com","stage":"private-large","investors":[],"funding":[]},"route":"/companies/polaris-group/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"}],"section":[{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"drug":[{"id":"adi-peg20","kind":"drug","name":"ADI-PEG20","route":"/drugs/adi-peg20/"}]}}