{"entity":{"id":"pole3","kind":"target","name":"POLE3","aka":["DNA polymerase epsilon 3, accessory subunit","DNA polymerase epsilon subunit 3","CHRAC17","Ybl1","p17","CHARAC17","CHRAC2"],"tldr":"POLE3 (DNA polymerase epsilon subunit 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma, Lung cancer and 5 more.","summary":"Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.14, genetic association 0.03, clinical 0.99).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13546","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13546"},{"label":"UniProt Q9NRF9","url":"https://www.uniprot.org/uniprotkb/Q9NRF9/entry"},{"label":"NCBI Gene 54107","url":"https://www.ncbi.nlm.nih.gov/gene/54107"},{"label":"Ensembl ENSG00000148229","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148229"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","lung-cancer","myeloproliferative-neoplasms","breast-cancer","ovarian","mds","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"POLE3","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:13546","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13546","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NRF9","url":"https://www.uniprot.org/uniprotkb/Q9NRF9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000148229","url":"https://platform.opentargets.org/target/ENSG00000148229/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.59, ovarian cancer 0.58, acute myeloid leukaemia 0.59, acute lymphoblastic leukaemia 0.60, B-cell chronic lymphocytic leukaemia 0.59, non-Hodgkin lymphoma 0.60 (GraphQL API, CC0)"}],"hgnc":"HGNC:13546","ensembl":"ENSG00000148229","uniprot":"Q9NRF9","entrez":"54107","biology":"Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. Location: Nucleus (UniProt). Locus 9q32 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)","Lung cancer: Open Targets association 0.59 with lung cancer (MONDO_0008903)","Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076)","Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170)"],"targetClass":"other","prevalence":[]},"route":"/targets/pole3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}