{"entity":{"id":"pop-rt","kind":"trial","name":"POP-RT","aka":[],"tldr":"POP-RT, from Mumbai, showed that treating the pelvic lymph nodes as well as the prostate improves disease control in high-risk prostate cancer, reviving a question earlier trials had left unanswered.","summary":"POP-RT randomised 224 men with high-risk, node-negative prostate cancer (most staged with PSMA PET) to image-guided prostate-only or whole-pelvic radiotherapy with two years of androgen deprivation. Five-year biochemical failure-free survival was 95 percent with pelvic radiotherapy and 81.2 percent with prostate-only treatment (hazard ratio 0.23), with better disease-free survival and more late urinary toxicity (Murthy and colleagues, Journal of Clinical Oncology 2021).","status":"positive","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT01952223","url":"https://clinicaltrials.gov/study/NCT01952223"},{"label":"JCO 2021","url":"https://doi.org/10.1200/JCO.20.03282"}],"tags":["radiation-wave4"],"related":[],"cancers":["prostate"],"sections":[],"technologies":["imrt-igrt","psma-pet"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT01952223","phase":"3","setting":"High-risk node-negative prostate cancer: prostate-only versus whole-pelvic radiotherapy, both with hormone therapy","sponsor":"Tata Memorial Centre, Mumbai","result":"5-year biochemical failure-free survival 95% (whole pelvis) vs 81.2% (prostate only).","yearReported":2021,"enrolled":224,"outcomes":[{"endpoint":"Biochemical failure-free survival at 5 years","primary":true,"unit":"%","arms":[{"name":"Whole-pelvic radiotherapy","n":110,"value":95},{"name":"Prostate-only radiotherapy","n":114,"value":81.2}]}]},"route":"/trials/pop-rt/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"psma-pet","kind":"technology","name":"PSMA PET","route":"/technologies/psma-pet/"}]}}