{"entity":{"id":"pou5f1","kind":"target","name":"POU5F1","aka":["POU class 5 homeobox 1","POU domain, class 5, transcription factor 1","OCT3","Oct4","MGC22487","OCT-4","Oct3/4","OTF3"],"tldr":"POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.","summary":"Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin. Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.36, genetic association 0.00, somatic mutation 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9221","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9221"},{"label":"UniProt Q01860","url":"https://www.uniprot.org/uniprotkb/Q01860/entry"},{"label":"NCBI Gene 5460","url":"https://www.ncbi.nlm.nih.gov/gene/5460"},{"label":"Ensembl ENSG00000204531","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204531"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["colorectal","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"POU5F1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9221","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9221","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q01860","url":"https://www.uniprot.org/uniprotkb/Q01860/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene POU5F1","url":"https://civicdb.org/features/4419","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colon Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000204531","url":"https://platform.opentargets.org/target/ENSG00000204531/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: lung cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:9221","ensembl":"ENSG00000204531","uniprot":"Q01860","entrez":"5460","biology":"Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Location: Cytoplasm; Nucleus (UniProt). Locus 6p21.33 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/pou5f1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}