{"entity":{"id":"pou5f1b","kind":"target","name":"POU5F1B","aka":["POU class 5 homeobox 1B","POU domain, class 5, transcription factor 1B","OTF3C","OTF3P1","POU5F1P1"],"tldr":"POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.","summary":"Shows weak transcriptional activator activity.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.85).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9223","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9223"},{"label":"UniProt Q06416","url":"https://www.uniprot.org/uniprotkb/Q06416/entry"},{"label":"NCBI Gene 5462","url":"https://www.ncbi.nlm.nih.gov/gene/5462"},{"label":"Ensembl ENSG00000212993","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000212993"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"POU5F1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9223","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9223","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q06416","url":"https://www.uniprot.org/uniprotkb/Q06416/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000212993","url":"https://platform.opentargets.org/target/ENSG00000212993/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.56, prostate cancer 0.64 (GraphQL API, CC0)"}],"hgnc":"HGNC:9223","ensembl":"ENSG00000212993","uniprot":"Q06416","entrez":"5462","biology":"Shows weak transcriptional activator activity. Location: Nucleus; Cytoplasm (UniProt). Locus 8q24.21 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.64 with prostate cancer (MONDO_0008315)","Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/pou5f1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}