{"entity":{"id":"ppfibp1","kind":"target","name":"PPFIBP1","aka":["PPFIB scaffold protein 1","Liprin-beta-1","L2","hSGT2","hSgt2p","SGT2","liprin-beta1"],"tldr":"PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.76, genetic association 0.04, somatic mutation 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9249","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9249"},{"label":"UniProt Q86W92","url":"https://www.uniprot.org/uniprotkb/Q86W92/entry"},{"label":"NCBI Gene 8496","url":"https://www.ncbi.nlm.nih.gov/gene/8496"},{"label":"Ensembl ENSG00000110841","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110841"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPFIBP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9249","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9249","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86W92","url":"https://www.uniprot.org/uniprotkb/Q86W92/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000110841","url":"https://platform.opentargets.org/target/ENSG00000110841/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9249","ensembl":"ENSG00000110841","uniprot":"Q86W92","entrez":"8496","biology":"May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Location: Cytoplasm, cell cortex (UniProt). Locus 12p11.23-p11.22 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ppfibp1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}