{"entity":{"id":"ppm1b","kind":"target","name":"PPM1B","aka":["protein phosphatase, Mg2+/Mn2+ dependent 1B","Protein phosphatase 1B","PPC2BETAX","PP2CB","PP2CBETA"],"tldr":"PPM1B (Protein phosphatase 1B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.78, affected pathway 0.83, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9276","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9276"},{"label":"UniProt O75688","url":"https://www.uniprot.org/uniprotkb/O75688/entry"},{"label":"NCBI Gene 5495","url":"https://www.ncbi.nlm.nih.gov/gene/5495"},{"label":"Ensembl ENSG00000138032","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138032"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPM1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9276","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9276","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75688","url":"https://www.uniprot.org/uniprotkb/O75688/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138032","url":"https://platform.opentargets.org/target/ENSG00000138032/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9276","ensembl":"ENSG00000138032","uniprot":"O75688","entrez":"5495","biology":"Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signalling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Location: Cytoplasm, cytosol; Membrane (UniProt). Locus 2p21 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ppm1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}