{"entity":{"id":"ppp1r14a","kind":"target","name":"PPP1R14A","aka":["protein phosphatase 1 regulatory inhibitor subunit 14A","Protein phosphatase 1 regulatory subunit 14A","CPI-17","PPP1INL"],"tldr":"PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.74).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14871"},{"label":"UniProt Q96A00","url":"https://www.uniprot.org/uniprotkb/Q96A00/entry"},{"label":"NCBI Gene 94274","url":"https://www.ncbi.nlm.nih.gov/gene/94274"},{"label":"Ensembl ENSG00000167641","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167641"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP1R14A","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14871","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96A00","url":"https://www.uniprot.org/uniprotkb/Q96A00/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000167641","url":"https://platform.opentargets.org/target/ENSG00000167641/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:14871","ensembl":"ENSG00000167641","uniprot":"Q96A00","entrez":"94274","biology":"Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Location: Cytoplasm (UniProt). Locus 19q13.1 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/ppp1r14a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}