{"entity":{"id":"ppp1r15a","kind":"target","name":"PPP1R15A","aka":["protein phosphatase 1 regulatory subunit 15A","Protein phosphatase 1 regulatory subunit 15A","GADD34"],"tldr":"PPP1R15A (Protein phosphatase 1 regulatory subunit 15A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signalling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Bevacizumab and FOLFIRI Regimen.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14375","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14375"},{"label":"UniProt O75807","url":"https://www.uniprot.org/uniprotkb/O75807/entry"},{"label":"NCBI Gene 23645","url":"https://www.ncbi.nlm.nih.gov/gene/23645"},{"label":"Ensembl ENSG00000087074","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000087074"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP1R15A","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:14375","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14375","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75807","url":"https://www.uniprot.org/uniprotkb/O75807/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PPP1R15A","url":"https://civicdb.org/features/9722","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:14375","ensembl":"ENSG00000087074","uniprot":"O75807","entrez":"23645","biology":"Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signalling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication. Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation. Location: Endoplasmic reticulum membrane; Mitochondrion outer membrane (UniProt). Locus 19q13.2 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ppp1r15a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}