{"entity":{"id":"ppp2ca","kind":"target","name":"PPP2CA","aka":["protein phosphatase 2 catalytic subunit alpha","Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform","PP2Calpha","PP2AC"],"tldr":"PPP2CA (Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes clinical 0.13, affected pathway 0.78, literature 0.87, genetic association 0.00, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9299","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9299"},{"label":"UniProt P67775","url":"https://www.uniprot.org/uniprotkb/P67775/entry"},{"label":"NCBI Gene 5515","url":"https://www.ncbi.nlm.nih.gov/gene/5515"},{"label":"Ensembl ENSG00000113575","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113575"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.13. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP2CA","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9299","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9299","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P67775","url":"https://www.uniprot.org/uniprotkb/P67775/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113575","url":"https://platform.opentargets.org/target/ENSG00000113575/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9299","ensembl":"ENSG00000113575","uniprot":"P67775","entrez":"5515","biology":"Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate various proteins, such as SV40 large T antigen, AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Location: Cytoplasm; Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus 5q31.1 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ppp2ca/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}