{"entity":{"id":"ppp2r1b","kind":"target","name":"PPP2R1B","aka":["protein phosphatase 2 scaffold subunit Abeta","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform","PR65B","PP2A-Abeta"],"tldr":"PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.\n\nOpen Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.89, genetic association 0.51, somatic mutation 0.55).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9303","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9303"},{"label":"UniProt P30154","url":"https://www.uniprot.org/uniprotkb/P30154/entry"},{"label":"NCBI Gene 5519","url":"https://www.ncbi.nlm.nih.gov/gene/5519"},{"label":"Ensembl ENSG00000137713","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137713"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP2R1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9303","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9303","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P30154","url":"https://www.uniprot.org/uniprotkb/P30154/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000137713","url":"https://platform.opentargets.org/target/ENSG00000137713/associations","note":"association with cancer (MONDO_0004992) 0.68;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9303","ensembl":"ENSG00000137713","uniprot":"P30154","entrez":"5519","biology":"The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Locus 11q23.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ppp2r1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}