{"entity":{"id":"ppp2r2a","kind":"target","name":"PPP2R2A","aka":["protein phosphatase 2 regulatory subunit Balpha","Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform","PR52A","PR55A","B55A","PR55alpha","B55alpha"],"tldr":"PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib and PARP Inhibitor ABT-888.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9304","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9304"},{"label":"UniProt P63151","url":"https://www.uniprot.org/uniprotkb/P63151/entry"},{"label":"NCBI Gene 5520","url":"https://www.ncbi.nlm.nih.gov/gene/5520"},{"label":"Ensembl ENSG00000221914","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221914"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP2R2A","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9304","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9304","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P63151","url":"https://www.uniprot.org/uniprotkb/P63151/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PPP2R2A","url":"https://civicdb.org/features/4465","note":"2 evidence items, 0 assertions, 2 variants; diseases: Cancer, Castration-resistant Prostate Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:9304","ensembl":"ENSG00000221914","uniprot":"P63151","entrez":"5520","biology":"Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Locus 8p21.2 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ppp2r2a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}