{"entity":{"id":"ppp2r5b","kind":"target","name":"PPP2R5B","aka":["protein phosphatase 2 regulatory subunit B'beta","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform","FLJ35411","B56B","PR61B","B56beta"],"tldr":"PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.89, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9310","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9310"},{"label":"UniProt Q15173","url":"https://www.uniprot.org/uniprotkb/Q15173/entry"},{"label":"NCBI Gene 5526","url":"https://www.ncbi.nlm.nih.gov/gene/5526"},{"label":"Ensembl ENSG00000068971","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000068971"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP2R5B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9310","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9310","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15173","url":"https://www.uniprot.org/uniprotkb/Q15173/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000068971","url":"https://platform.opentargets.org/target/ENSG00000068971/associations","note":"association with cancer (MONDO_0004992) 0.55;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9310","ensembl":"ENSG00000068971","uniprot":"Q15173","entrez":"5526","biology":"As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Location: Cytoplasm (UniProt). Locus 11q13.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ppp2r5b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}