{"entity":{"id":"ppp2r5e","kind":"target","name":"PPP2R5E","aka":["protein phosphatase 2 regulatory subunit B'epsilon","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform","B56E","B56epsilon"],"tldr":"PPP2R5E (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.89, genetic association 0.07).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9313","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9313"},{"label":"UniProt Q16537","url":"https://www.uniprot.org/uniprotkb/Q16537/entry"},{"label":"NCBI Gene 5529","url":"https://www.ncbi.nlm.nih.gov/gene/5529"},{"label":"Ensembl ENSG00000154001","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154001"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP2R5E","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9313","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9313","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16537","url":"https://www.uniprot.org/uniprotkb/Q16537/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000154001","url":"https://platform.opentargets.org/target/ENSG00000154001/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9313","ensembl":"ENSG00000154001","uniprot":"Q16537","entrez":"5529","biology":"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localisation of the catalytic enzyme to a particular subcellular compartment. Location: Cytoplasm (UniProt). Locus 14q23.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ppp2r5e/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}