{"entity":{"id":"ppp3ca","kind":"target","name":"PPP3CA","aka":["protein phosphatase 3 catalytic subunit alpha","Protein phosphatase 3 catalytic subunit alpha","CNA1","PPP2B","CALNA"],"tldr":"PPP3CA (Protein phosphatase 3 catalytic subunit alpha) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Stomach Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9314","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9314"},{"label":"UniProt Q08209","url":"https://www.uniprot.org/uniprotkb/Q08209/entry"},{"label":"NCBI Gene 5530","url":"https://www.ncbi.nlm.nih.gov/gene/5530"},{"label":"Ensembl ENSG00000138814","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138814"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PPP3CA","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9314","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9314","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q08209","url":"https://www.uniprot.org/uniprotkb/Q08209/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PPP3CA","url":"https://www.intogen.org/search?gene=PPP3CA","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9314","ensembl":"ENSG00000138814","uniprot":"Q08209","entrez":"5530","biology":"Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarisation, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. Dephosphorylates heat shock protein HSPB1. Location: Cytoplasm; Cell membrane; Cell membrane, sarcolemma; Cytoplasm, myofibril, sarcomere, Z line (UniProt). Locus 4q24 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ppp3ca/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}