{"entity":{"id":"prc1","kind":"target","name":"PRC1","aka":["protein regulator of cytokinesis 1","Protein regulator of cytokinesis 1","ASE1","MAP65"],"tldr":"PRC1 (Protein regulator of cytokinesis 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localisation to the central spindle and midbody.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.98, animal model 0.53, genetic association 0.75).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9341","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9341"},{"label":"UniProt O43663","url":"https://www.uniprot.org/uniprotkb/O43663/entry"},{"label":"NCBI Gene 9055","url":"https://www.ncbi.nlm.nih.gov/gene/9055"},{"label":"Ensembl ENSG00000198901","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198901"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRC1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9341","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9341","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43663","url":"https://www.uniprot.org/uniprotkb/O43663/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198901","url":"https://platform.opentargets.org/target/ENSG00000198901/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: breast cancer 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:9341","ensembl":"ENSG00000198901","uniprot":"O43663","entrez":"9055","biology":"Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localisation to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton, spindle pole; Midbody (UniProt). Locus 15q26.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)"],"targetClass":"other","prevalence":[]},"route":"/targets/prc1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}