{"entity":{"id":"prdm2","kind":"target","name":"PRDM2","aka":["PR/SET domain 2","PR domain zinc finger protein 2","RIZ1","RIZ2","KMT8","MTB-ZF","HUMHOXY1","KMT8A"],"tldr":"PRDM2 (PR domain zinc finger protein 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Renal cell carcinoma, Neuroblastoma and 1 more.","summary":"S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.\n\nIntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Neuroblastoma, Papillary Renal Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9347","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9347"},{"label":"UniProt Q13029","url":"https://www.uniprot.org/uniprotkb/Q13029/entry"},{"label":"NCBI Gene 7799","url":"https://www.ncbi.nlm.nih.gov/gene/7799"},{"label":"Ensembl ENSG00000116731","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116731"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["hcc","rcc","neuroblastoma","papillary-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRDM2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9347","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9347","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13029","url":"https://www.uniprot.org/uniprotkb/Q13029/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PRDM2","url":"https://www.intogen.org/search?gene=PRDM2","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9347","ensembl":"ENSG00000116731","uniprot":"Q13029","entrez":"7799","biology":"S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Location: Nucleus (UniProt). Locus 1p36.21 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)","Neuroblastoma: IntOGen driver in 1 cohort (NBL)","Papillary renal cell carcinoma: IntOGen driver in 1 cohort (PRCC)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/prdm2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"papillary-rcc","kind":"cancer","name":"Papillary renal cell carcinoma","route":"/cancers/papillary-rcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}