{"entity":{"id":"prkce","kind":"target","name":"PRKCE","aka":["protein kinase C epsilon","Protein kinase C epsilon type"],"tldr":"PRKCE (Protein kinase C epsilon type) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Systemic mastocytosis and 1 more.","summary":"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signalling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.45, clinical 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9401","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9401"},{"label":"UniProt Q02156","url":"https://www.uniprot.org/uniprotkb/Q02156/entry"},{"label":"NCBI Gene 5581","url":"https://www.ncbi.nlm.nih.gov/gene/5581"},{"label":"Ensembl ENSG00000171132","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171132"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","systemic-mastocytosis","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRKCE","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:9401","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9401","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q02156","url":"https://www.uniprot.org/uniprotkb/Q02156/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000171132","url":"https://platform.opentargets.org/target/ENSG00000171132/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.58, myeloproliferative neoplasm 0.58, systemic mastocytosis 0.54, leukaemia 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:9401","ensembl":"ENSG00000171132","uniprot":"Q02156","entrez":"5581","biology":"Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signalling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cell membrane; Cytoplasm, perinuclear region (UniProt). Locus 2p21 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.58 with myeloproliferative neoplasm (MONDO_0020076)","Systemic mastocytosis: Open Targets association 0.54 with systemic mastocytosis (MONDO_0016586)","Acute myeloid leukaemia: Open Targets association 0.58 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/prkce/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"systemic-mastocytosis","kind":"cancer","name":"Systemic mastocytosis","route":"/cancers/systemic-mastocytosis/"}]}}