{"entity":{"id":"prkch","kind":"target","name":"PRKCH","aka":["protein kinase C eta","PRKCH upstream open reading frame 2","PKC-L","PRKCL"],"tldr":"PRKCH (PRKCH upstream open reading frame 2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Systemic mastocytosis and 1 more.","summary":"Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF. Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner. In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes clinical 0.92, affected pathway 0.76, literature 0.92, genetic association 0.07, animal model 0.42).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9403","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9403"},{"label":"UniProt C0HM02","url":"https://www.uniprot.org/uniprotkb/C0HM02/entry"},{"label":"NCBI Gene 5583","url":"https://www.ncbi.nlm.nih.gov/gene/5583"},{"label":"Ensembl ENSG00000027075","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000027075"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","systemic-mastocytosis","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRKCH","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:9403","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9403","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt C0HM02","url":"https://www.uniprot.org/uniprotkb/C0HM02/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000027075","url":"https://platform.opentargets.org/target/ENSG00000027075/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.56, myeloproliferative neoplasm 0.62, systemic mastocytosis 0.54, leukaemia 0.63 (GraphQL API, CC0)"}],"hgnc":"HGNC:9403","ensembl":"ENSG00000027075","uniprot":"C0HM02","entrez":"5583","biology":"Product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF. Functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner. In addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ and PRKCE but not PRKCA, PRKCG or PRKCZ. Locus 14q23.1 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.62 with myeloproliferative neoplasm (MONDO_0020076)","Systemic mastocytosis: Open Targets association 0.54 with systemic mastocytosis (MONDO_0016586)","Acute myeloid leukaemia: Open Targets association 0.56 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"other","prevalence":[]},"route":"/targets/prkch/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"systemic-mastocytosis","kind":"cancer","name":"Systemic mastocytosis","route":"/cancers/systemic-mastocytosis/"}]}}