{"entity":{"id":"prkd3","kind":"target","name":"PRKD3","aka":["protein kinase D3","Serine/threonine-protein kinase D3","PKD3","EPK2","PRKCN"],"tldr":"PRKD3 (Serine/threonine-protein kinase D3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms, Systemic mastocytosis and 1 more.","summary":"Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.96, animal model 0.42, genetic association 0.00, clinical 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9408","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9408"},{"label":"UniProt O94806","url":"https://www.uniprot.org/uniprotkb/O94806/entry"},{"label":"NCBI Gene 23683","url":"https://www.ncbi.nlm.nih.gov/gene/23683"},{"label":"Ensembl ENSG00000115825","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115825"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","myeloproliferative-neoplasms","systemic-mastocytosis","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.94. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRKD3","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:9408","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9408","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O94806","url":"https://www.uniprot.org/uniprotkb/O94806/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000115825","url":"https://platform.opentargets.org/target/ENSG00000115825/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.56, myeloproliferative neoplasm 0.56, systemic mastocytosis 0.54, leukaemia 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:9408","ensembl":"ENSG00000115825","uniprot":"O94806","entrez":"23683","biology":"Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress. Location: Cytoplasm; Membrane (UniProt). Locus 2p22.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.56 with myeloproliferative neoplasm (MONDO_0020076)","Systemic mastocytosis: Open Targets association 0.54 with systemic mastocytosis (MONDO_0016586)","Acute myeloid leukaemia: Open Targets association 0.56 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/prkd3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"systemic-mastocytosis","kind":"cancer","name":"Systemic mastocytosis","route":"/cancers/systemic-mastocytosis/"}]}}