{"entity":{"id":"prkn","kind":"target","name":"PRKN","aka":["parkin RBR E3 ubiquitin protein ligase","E3 ubiquitin-protein ligase parkin","AR-JP","parkin","PARK2"],"tldr":"PRKN (E3 ubiquitin-protein ligase parkin) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer and Ovarian cancer.","summary":"Functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Phosphatidylinositide 3-Kinase Inhibitor. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.85).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8607"},{"label":"UniProt O60260","url":"https://www.uniprot.org/uniprotkb/O60260/entry"},{"label":"NCBI Gene 5071","url":"https://www.ncbi.nlm.nih.gov/gene/5071"},{"label":"Ensembl ENSG00000185345","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185345"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["lung-cancer","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRKN","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:8607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8607","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60260","url":"https://www.uniprot.org/uniprotkb/O60260/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PRKN","url":"https://civicdb.org/features/4103","note":"2 evidence items, 0 assertions, 2 variants; diseases: Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000185345","url":"https://platform.opentargets.org/target/ENSG00000185345/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: ovarian cancer 0.57, lung cancer 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:8607","ensembl":"ENSG00000185345","uniprot":"O60260","entrez":"5071","biology":"Functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognised by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Location: Cytoplasm, cytosol; Nucleus; Endoplasmic reticulum; Mitochondrion (UniProt). Locus 6q26 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.58 with lung cancer (MONDO_0008903)","Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/prkn/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}