{"entity":{"id":"protagonist-therapeutics","kind":"company","name":"Protagonist Therapeutics","aka":["Protagonist Therapeutics, Inc.","Protagonist"],"tldr":"Protagonist is a California peptide company whose hepcidin mimetic rusfertide controls the excess red cell production of polycythaemia vera without repeated phlebotomy, with positive phase 3 VERIFY results in 2025 and a partnership with Takeda.","summary":"Protagonist Therapeutics, listed on Nasdaq, designs peptide medicines. Rusfertide, an injectable mimetic of the iron hormone hepcidin, restricts iron available for red cell production and in the phase 3 VERIFY trial reduced the need for phlebotomy in polycythaemia vera, a chronic myeloproliferative blood cancer; Takeda licensed the drug in 2024. The company's other lead, the oral IL-23 receptor antagonist icotrokinra, is partnered with Johnson & Johnson in psoriasis. It appears on OnCo as a lead sponsor of phase 3 cancer trials on ClinicalTrials.gov.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://www.protagonist-inc.com"},{"label":"ClinicalTrials.gov: trials led by Protagonist Therapeutics","url":"https://clinicaltrials.gov/search?lead=Protagonist%20Therapeutics"}],"tags":["ctgov-sponsor"],"related":[],"cancers":[],"sections":["targeted-therapy"],"technologies":[],"targets":[],"drugs":["rusfertide"],"companies":["takeda"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Newark, CA","country":"US","companyType":"biotech","website":"https://www.protagonist-inc.com","stage":"public","investors":[],"funding":[]},"route":"/companies/protagonist-therapeutics/","neighbours":{"section":[{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"drug":[{"id":"rusfertide","kind":"drug","name":"Rusfertide","route":"/drugs/rusfertide/"}],"company":[{"id":"takeda","kind":"company","name":"Takeda","route":"/companies/takeda/"}]}}