{"entity":{"id":"prps1","kind":"target","name":"PRPS1","aka":["phosphoribosyl pyrophosphate synthetase 1","Ribose-phosphate pyrophosphokinase 1","CMTX5","DFNX1","PRS-I","PPRibP","DFN2"],"tldr":"PRPS1 (Ribose-phosphate pyrophosphokinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute lymphoblastic leukaemia.","summary":"Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.\n\nCIViC holds 45 clinical evidence items and 0 assertions across 21 variants, naming Mercaptopurine, Thioguanine, Daunorubicin and Cytarabine and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9462","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9462"},{"label":"UniProt P60891","url":"https://www.uniprot.org/uniprotkb/P60891/entry"},{"label":"NCBI Gene 5631","url":"https://www.ncbi.nlm.nih.gov/gene/5631"},{"label":"Ensembl ENSG00000147224","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147224"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 7 therapies; CIViC holds 45 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRPS1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9462","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9462","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P60891","url":"https://www.uniprot.org/uniprotkb/P60891/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PRPS1","url":"https://civicdb.org/features/4566","note":"45 evidence items, 0 assertions, 21 variants; diseases: B-lymphoblastic Leukaemia/lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:9462","ensembl":"ENSG00000147224","uniprot":"P60891","entrez":"5631","biology":"Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Locus Xq22.3 (HGNC).","whereFound":["Acute lymphoblastic leukaemia: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/prps1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"}]}}