{"entity":{"id":"prune2","kind":"target","name":"PRUNE2","aka":["prune homolog 2 with BCH domain","Protein prune homolog 2","BMCC1","BNIPXL","A214N16.3","bA214N16.3","C9orf65","KIAA0367"],"tldr":"PRUNE2 (Protein prune homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroblastoma.","summary":"May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25209","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25209"},{"label":"UniProt Q8WUY3","url":"https://www.uniprot.org/uniprotkb/Q8WUY3/entry"},{"label":"NCBI Gene 158471","url":"https://www.ncbi.nlm.nih.gov/gene/158471"},{"label":"Ensembl ENSG00000106772","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106772"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PRUNE2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25209","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25209","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WUY3","url":"https://www.uniprot.org/uniprotkb/Q8WUY3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PRUNE2","url":"https://www.intogen.org/search?gene=PRUNE2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25209","ensembl":"ENSG00000106772","uniprot":"Q8WUY3","entrez":"158471","biology":"May play an important role in regulating differentiation, survival and aggressiveness of the tumour cells. Location: Cytoplasm (UniProt). Locus 9q21.2 (HGNC).","whereFound":["Neuroblastoma: IntOGen driver in 1 cohort (NBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/prune2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"}]}}