{"entity":{"id":"psa-doubling-time","kind":"term","name":"PSA doubling time","aka":["PSADT"],"tldr":"How long the PSA takes to double, used to tell a slow rise from a fast one.","summary":"NICE NG131 asks for it to be estimated from at least three measurements over at least six months when the PSA rises after treatment, and uses a doubling time of less than three months as one of the three reasons to start hormone therapy for a biochemical relapse. The speed carries more information than the number itself, which is why a single raised reading is not treated as an event.","asOf":"2026-09-25","links":[{"label":"NICE NG131: prostate cancer, diagnosis and management","url":"https://www.nice.org.uk/guidance/ng131/chapter/Recommendations"}],"tags":[],"related":["metastasis-free-survival"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["metastasis-free-survival"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Biomarkers"},"route":"/terms/psa-doubling-time/","neighbours":{"term":[{"id":"metastasis-free-survival","kind":"term","name":"Metastasis-free survival (MFS)","route":"/terms/metastasis-free-survival/"}],"cancer":[{"id":"prostate-nmcrpc","kind":"cancer","name":"Non-metastatic castration-resistant prostate cancer","route":"/cancers/prostate-nmcrpc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"trial":[{"id":"embark","kind":"trial","name":"EMBARK","route":"/trials/embark/"}]}}