{"entity":{"id":"psma8","kind":"target","name":"PSMA8","aka":["proteasome 20S subunit alpha 8","Proteasome subunit alpha-type 8","MGC26605","PSMA7L"],"tldr":"PSMA8 (Proteasome subunit alpha-type 8) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.","summary":"Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.09, genetic association 0.09, clinical 0.99).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:22985","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22985"},{"label":"UniProt Q8TAA3","url":"https://www.uniprot.org/uniprotkb/Q8TAA3/entry"},{"label":"NCBI Gene 143471","url":"https://www.ncbi.nlm.nih.gov/gene/143471"},{"label":"Ensembl ENSG00000154611","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154611"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["multiple-myeloma","non-hodgkin-lymphoma","mantle-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PSMA8","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:22985","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22985","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8TAA3","url":"https://www.uniprot.org/uniprotkb/Q8TAA3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000154611","url":"https://platform.opentargets.org/target/ENSG00000154611/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:22985","ensembl":"ENSG00000154611","uniprot":"Q8TAA3","entrez":"143471","biology":"Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localises to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. Location: Nucleus (UniProt). Locus 18q11.2 (HGNC).","whereFound":["Multiple myeloma: Open Targets association 0.60 with plasma cell myeloma (MONDO_0009693)","Non-Hodgkin lymphoma: Open Targets association 0.57 with non-Hodgkin lymphoma (MONDO_0018908)","Mantle cell lymphoma: Open Targets association 0.54 with mantle cell lymphoma (MONDO_0018876)"],"targetClass":"other","prevalence":[]},"route":"/targets/psma8/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}