{"entity":{"id":"ptk6","kind":"target","name":"PTK6 (BRK)","aka":[],"tldr":"PTK6, also called breast tumour kinase, is over-expressed in most breast cancers and is one of the off-targets of dasatinib; drugs made specifically against it are still experimental.","summary":"Protein tyrosine kinase 6, or breast tumour kinase (BRK), is a distant relative of the SRC family that is normally found in differentiating gut and skin epithelium but is over-expressed in the majority of breast cancers and in some colon, prostate and ovarian tumours, where it promotes proliferation, survival and migration through STAT3 and AKT. It appears in ChEMBL as a target because approved multi-kinase inhibitors, dasatinib among them, inhibit it; selective PTK6 inhibitors and degraders are in preclinical development, including for HER2-positive and triple-negative breast cancer.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/PTK6","links":[{"label":"UniProt Q13882: PTK6","url":"https://www.uniprot.org/uniprotkb/Q13882/entry"},{"label":"HGNC:9617 PTK6","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9617"},{"label":"ChEMBL target CHEMBL4601","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL4601"}],"tags":["chembl-gap"],"related":["her2","egfr","src"],"cancers":["breast-her2-positive","tnbc","colorectal","prostate"],"sections":[],"technologies":[],"targets":[],"drugs":["dasatinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"PTK6","biology":"An intracellular non-receptor tyrosine kinase lacking a membrane anchor; in tumours it phosphorylates STAT3, paxillin and Sam68 and cooperates with HER2 and EGFR signalling.","whereFound":["Differentiated intestinal and skin epithelium","Most breast cancers; some colon, prostate and ovarian cancers"],"targetClass":"kinase","prevalence":[]},"route":"/targets/ptk6/","neighbours":{"target":[{"id":"egfr","kind":"target","name":"EGFR","route":"/targets/egfr/"},{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"},{"id":"src","kind":"target","name":"SRC family kinases","route":"/targets/src/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"drug":[{"id":"dasatinib","kind":"drug","name":"Dasatinib","route":"/drugs/dasatinib/"}]}}