{"entity":{"id":"ptma","kind":"target","name":"PTMA","aka":["prothymosin alpha","Prothymosin alpha"],"tldr":"PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.","summary":"Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Mixed Germ Cell Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9623","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9623"},{"label":"UniProt P06454","url":"https://www.uniprot.org/uniprotkb/P06454/entry"},{"label":"NCBI Gene 5757","url":"https://www.ncbi.nlm.nih.gov/gene/5757"},{"label":"Ensembl ENSG00000187514","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187514"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["testicular"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTMA","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9623","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9623","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P06454","url":"https://www.uniprot.org/uniprotkb/P06454/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PTMA","url":"https://www.intogen.org/search?gene=PTMA","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9623","ensembl":"ENSG00000187514","uniprot":"P06454","entrez":"5757","biology":"Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Location: Nucleus (UniProt). Locus 2q37.1 (HGNC).","whereFound":["Testicular germ cell tumours: IntOGen driver in 1 cohort (MGCT)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/ptma/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"testicular","kind":"cancer","name":"Testicular germ cell tumours","route":"/cancers/testicular/"}]}}