{"entity":{"id":"ptp4a3","kind":"target","name":"PTP4A3","aka":["protein tyrosine phosphatase 4A3","Protein tyrosine phosphatase type IVA 3","PRL-3","PRL-R","PRL3"],"tldr":"PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9636","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9636"},{"label":"UniProt O75365","url":"https://www.uniprot.org/uniprotkb/O75365/entry"},{"label":"NCBI Gene 11156","url":"https://www.ncbi.nlm.nih.gov/gene/11156"},{"label":"Ensembl ENSG00000184489","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184489"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct04452955","nct07290088","nct07541001"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTP4A3","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9636","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9636","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75365","url":"https://www.uniprot.org/uniprotkb/O75365/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTP4A3","url":"https://civicdb.org/features/8908","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:9636","ensembl":"ENSG00000184489","uniprot":"O75365","entrez":"11156","biology":"Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II. Location: Cell membrane; Early endosome (UniProt). Locus 8q24.3 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptp4a3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"trial":[{"id":"nct04452955","kind":"trial","name":"A Study to Assess Safety and Efficacy of PRL3-Zumab in Patients With Solid Tumors","route":"/trials/nct04452955/"},{"id":"nct07290088","kind":"trial","name":"Phase II/III Trial of PRL3-Zumab in Advanced Solid Tumor Patients","route":"/trials/nct07290088/"},{"id":"nct07541001","kind":"trial","name":"PRL3-Zumab in Patients With Advanced Solid Tumors","route":"/trials/nct07541001/"}]}}