{"entity":{"id":"ptpn12","kind":"target","name":"PTPN12","aka":["protein tyrosine phosphatase non-receptor type 12","Tyrosine-protein phosphatase non-receptor type 12","PTPG1","PTP-PEST"],"tldr":"PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.","summary":"Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Crizotinib and Sunitinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9645","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9645"},{"label":"UniProt Q05209","url":"https://www.uniprot.org/uniprotkb/Q05209/entry"},{"label":"NCBI Gene 5782","url":"https://www.ncbi.nlm.nih.gov/gene/5782"},{"label":"Ensembl ENSG00000127947","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127947"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPN12","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9645","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9645","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q05209","url":"https://www.uniprot.org/uniprotkb/Q05209/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPN12","url":"https://civicdb.org/features/4686","note":"1 evidence items, 0 assertions, 1 variants; diseases: Triple-negative Breast Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:9645","ensembl":"ENSG00000127947","uniprot":"Q05209","entrez":"5782","biology":"Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. Location: Cytoplasm; Cell junction, focal adhesion; Cell projection, podosome (UniProt). Locus 7q11.23 (HGNC).","whereFound":["Triple-negative breast cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptpn12/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}]}}