{"entity":{"id":"ptpn13","kind":"target","name":"PTPN13","aka":["protein tyrosine phosphatase non-receptor type 13","Tyrosine-protein phosphatase non-receptor type 13","PTP1E","PTP-BAS","PTPL1","PTP-BL"],"tldr":"PTPN13 (Tyrosine-protein phosphatase non-receptor type 13) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Pancreatic ductal adenocarcinoma, Endometrial cancer and 3 more.","summary":"Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.86). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreas, Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9646","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9646"},{"label":"UniProt Q12923","url":"https://www.uniprot.org/uniprotkb/Q12923/entry"},{"label":"NCBI Gene 5783","url":"https://www.ncbi.nlm.nih.gov/gene/5783"},{"label":"Ensembl ENSG00000163629","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163629"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["urothelial","pancreatic","endometrial","breast-cancer","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPN13","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9646","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9646","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q12923","url":"https://www.uniprot.org/uniprotkb/Q12923/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000163629","url":"https://platform.opentargets.org/target/ENSG00000163629/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.54, breast cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen PTPN13","url":"https://www.intogen.org/search?gene=PTPN13","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9646","ensembl":"ENSG00000163629","uniprot":"Q12923","entrez":"5783","biology":"Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling. May regulate phosphoinositide 3-kinase (PI3K) signalling through dephosphorylation of PIK3R2. Location: Cytoplasm, cytoskeleton; Nucleus; Cell projection, lamellipodium (UniProt). Locus 4q21.3 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PANCREAS)","Endometrial cancer: IntOGen driver in 1 cohort (UCEC)","Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptpn13/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}