{"entity":{"id":"ptpn3","kind":"target","name":"PTPN3","aka":["protein tyrosine phosphatase non-receptor type 3","Tyrosine-protein phosphatase non-receptor type 3","PTPH1"],"tldr":"PTPN3 (Tyrosine-protein phosphatase non-receptor type 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.","summary":"May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9655","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9655"},{"label":"UniProt P26045","url":"https://www.uniprot.org/uniprotkb/P26045/entry"},{"label":"NCBI Gene 5774","url":"https://www.ncbi.nlm.nih.gov/gene/5774"},{"label":"Ensembl ENSG00000070159","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070159"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPN3","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9655","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9655","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P26045","url":"https://www.uniprot.org/uniprotkb/P26045/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PTPN3","url":"https://www.intogen.org/search?gene=PTPN3","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9655","ensembl":"ENSG00000070159","uniprot":"P26045","entrez":"5774","biology":"May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Location: Cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 9q31.3 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ptpn3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}