{"entity":{"id":"ptprk","kind":"target","name":"PTPRK","aka":["protein tyrosine phosphatase receptor type K","Receptor-type tyrosine-protein phosphatase kappa","R-PTP-kappa"],"tldr":"PTPRK (Receptor-type tyrosine-protein phosphatase kappa) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Bladder & urothelial cancer, Renal cell carcinoma and 5 more.","summary":"Regulation of processes involving cell contact and adhesion such as growth control, tumour invasion, and metastasis. Negative regulator of EGFR signalling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin.\n\nOpen Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.93, animal model 0.59, genetic association 0.50, somatic mutation 0.85). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Renal Clear Cell Carcinoma, Non-Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9674","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9674"},{"label":"UniProt Q15262","url":"https://www.uniprot.org/uniprotkb/Q15262/entry"},{"label":"NCBI Gene 5796","url":"https://www.ncbi.nlm.nih.gov/gene/5796"},{"label":"Ensembl ENSG00000152894","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000152894"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","urothelial","rcc","skin-cancer","colorectal","melanoma","clear-cell-rcc","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPRK","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9674","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9674","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15262","url":"https://www.uniprot.org/uniprotkb/Q15262/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000152894","url":"https://platform.opentargets.org/target/ENSG00000152894/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.58, skin cancer 0.56, breast cancer 0.57 (GraphQL API, CC0)"},{"label":"IntOGen PTPRK","url":"https://www.intogen.org/search?gene=PTPRK","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9674","ensembl":"ENSG00000152894","uniprot":"Q15262","entrez":"5796","biology":"Regulation of processes involving cell contact and adhesion such as growth control, tumour invasion, and metastasis. Negative regulator of EGFR signalling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Location: Cell junction, adherens junction; Cell membrane (UniProt). Locus 6q22.33 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Melanoma: Open Targets association 0.58 with melanoma (MONDO_0005105)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptprk/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}