{"entity":{"id":"ptprt","kind":"target","name":"PTPRT","aka":["protein tyrosine phosphatase receptor type T","Receptor-type tyrosine-protein phosphatase T","RPTPrho","KIAA0283"],"tldr":"PTPRT (Receptor-type tyrosine-protein phosphatase T) is an enzyme. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer and 5 more.","summary":"May be involved in both signal transduction and cellular adhesion in the CNS.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming JSI-124 and Stattic. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.94, animal model 0.62, genetic association 0.32, somatic mutation 0.90). IntOGen calls it a driver in 8 cohorts (7 activating, 1 loss-of-function), covering Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Head and Neck Squamous Cell Carcinoma, Melanoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9682"},{"label":"UniProt O14522","url":"https://www.uniprot.org/uniprotkb/O14522/entry"},{"label":"NCBI Gene 11122","url":"https://www.ncbi.nlm.nih.gov/gene/11122"},{"label":"Ensembl ENSG00000196090","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196090"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["head-and-neck","esophageal","gastric","ovarian","hcc","pancreatic","skin-cancer","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; IntOGen calls it an activating (Act) driver in 7 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PTPRT","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9682","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9682","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14522","url":"https://www.uniprot.org/uniprotkb/O14522/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PTPRT","url":"https://civicdb.org/features/8878","note":"1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000196090","url":"https://platform.opentargets.org/target/ENSG00000196090/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: gastric cancer 0.54, oesophageal cancer 0.54, ovarian cancer 0.50, melanoma 0.59, thyroid cancer 0.52, neuroendocrine neoplasm 0.52 (GraphQL API, CC0)"},{"label":"IntOGen PTPRT","url":"https://www.intogen.org/search?gene=PTPRT","note":"driver in 8 cohorts (Act 7, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9682","ensembl":"ENSG00000196090","uniprot":"O14522","entrez":"11122","biology":"May be involved in both signal transduction and cellular adhesion in the CNS. Location: Membrane (UniProt). Locus 20q12-q13.11 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (HNSC)","Oesophageal cancer: Open Targets association 0.54 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.54 with gastric cancer (MONDO_0001056); IntOGen driver in 1 cohort (STAD)","Ovarian cancer: Open Targets association 0.50 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ptprt/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}