{"entity":{"id":"ptry","kind":"drug","name":"PTRY","aka":[],"tldr":"PTRY is an experimental trispecific T-cell engager from Chiome Bioscience, in preclinical development for malignant mesothelioma, small cell lung cancer and non-small cell lung cancer and other cancers.","summary":"PTRY is a trispecific T-cell engager (Tribody: 5T4, CD3 and PD-L1) from Chiome Bioscience. A humanized 5T4/CD3/PD-L1 multispecific antibody built with Tribody technology, which has three binding sites. Its furthest stage is preclinical development, for malignant mesothelioma, small cell lung cancer, non-small cell lung cancer and triple-negative breast cancer. No clinical trial naming it is registered on ClinicalTrials.gov. Pipeline page: 'Data is being obtained for outsourcing'. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Chiome Bioscience: chiome.co.jp","url":"https://www.chiome.co.jp/en/pipeline/"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["cd3","pdl1"],"drugs":[],"companies":["chiome-bioscience"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"PTRY","modality":"Trispecific T-cell engager (Tribody: 5T4, CD3 and PD-L1)","mechanism":"A humanized 5T4/CD3/PD-L1 multispecific antibody built with Tribody technology, which has three binding sites.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ptry/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"cd3","kind":"target","name":"CD3","route":"/targets/cd3/"},{"id":"pdl1","kind":"target","name":"PD-L1","route":"/targets/pdl1/"}],"company":[{"id":"chiome-bioscience","kind":"company","name":"Chiome Bioscience","route":"/companies/chiome-bioscience/"}]}}