{"entity":{"id":"ptt-4256","kind":"drug","name":"PTT-4256","aka":[],"tldr":"PTT-4256 is an experimental oral small molecule from Pathios Therapeutics, in phase 1 trials for advanced solid tumours.","summary":"PTT-4256 is an oral small molecule from Pathios Therapeutics. An orally bioavailable, selective inhibitor of GPR65, an acid-sensing receptor on immune cells; the company's case is that the acidic tumour environment acts through GPR65 to switch immune cells into a suppressed, pro-tumour state. Its furthest stage is phase 1, for advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 RAISIC-1 NCT06634849 recruiting (Australia). Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Pathios Therapeutics: pathios.com","url":"https://pathios.com/"},{"label":"Pathios Therapeutics: pathios.com","url":"https://pathios.com/"},{"label":"Pathios Therapeutics: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT06634849"},{"label":"ClinicalTrials.gov: trials of PTT-4256","url":"https://clinicaltrials.gov/search?intr=PTT-4256"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["gpr65"],"drugs":[],"companies":["pathios-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06634849"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"PTT-4256","modality":"Oral small molecule","mechanism":"An orally bioavailable, selective inhibitor of GPR65, an acid-sensing receptor on immune cells; the company's case is that the acidic tumour environment acts through GPR65 to switch immune cells into a suppressed, pro-tumour state.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ptt-4256/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"gpr65","kind":"target","name":"GPR65","route":"/targets/gpr65/"}],"company":[{"id":"pathios-therapeutics","kind":"company","name":"Pathios Therapeutics","route":"/companies/pathios-therapeutics/"}],"trial":[{"id":"nct06634849","kind":"trial","name":"An Open Label Dose Finding Study of PTT-4256 in Patients With Solid Tumours (RAISIC-1).","route":"/trials/nct06634849/"}]}}