{"entity":{"id":"pxdnl","kind":"target","name":"PXDNL","aka":["peroxidasin like","Probable oxidoreductase PXDNL","FLJ25471","PMR1"],"tldr":"PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:26359","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26359"},{"label":"UniProt A1KZ92","url":"https://www.uniprot.org/uniprotkb/A1KZ92/entry"},{"label":"NCBI Gene 137902","url":"https://www.ncbi.nlm.nih.gov/gene/137902"},{"label":"Ensembl ENSG00000147485","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147485"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PXDNL","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:26359","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26359","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A1KZ92","url":"https://www.uniprot.org/uniprotkb/A1KZ92/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene PXDNL","url":"https://civicdb.org/features/18364","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:26359","ensembl":"ENSG00000147485","uniprot":"A1KZ92","entrez":"137902","biology":"Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction. Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. Location: Secreted; Endoplasmic reticulum; Cell membrane; Cytoplasm (UniProt). Locus 8q11.22-q11.23 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/pxdnl/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}