{"entity":{"id":"qki","kind":"target","name":"QKI","aka":["QKI, KH domain containing RNA binding","KH domain-containing RNA-binding protein QKI","QK3"],"tldr":"QKI (KH domain-containing RNA-binding protein QKI) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer, Colorectal cancer and 3 more.","summary":"RNA reader protein, which recognises and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.97, genetic association 0.00, somatic mutation 0.82, animal model 0.47). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21100","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21100"},{"label":"UniProt Q96PU8","url":"https://www.uniprot.org/uniprotkb/Q96PU8/entry"},{"label":"NCBI Gene 9444","url":"https://www.ncbi.nlm.nih.gov/gene/9444"},{"label":"Ensembl ENSG00000112531","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112531"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","skin-cancer","colorectal","gastric","melanoma","glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"QKI","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:21100","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21100","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96PU8","url":"https://www.uniprot.org/uniprotkb/Q96PU8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000112531","url":"https://platform.opentargets.org/target/ENSG00000112531/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.51, gastric cancer 0.50, melanoma 0.57, skin cancer 0.54, breast cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen QKI","url":"https://www.intogen.org/search?gene=QKI","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:21100","ensembl":"ENSG00000112531","uniprot":"Q96PU8","entrez":"9444","biology":"RNA reader protein, which recognises and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognises and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularisation of pre-mRNAs. Location: Nucleus; Cytoplasm; Cytoplasm, cytosol; Cytoplasm, Stress granule (UniProt). Locus 6q26 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)","Melanoma: Open Targets association 0.57 with melanoma (MONDO_0005105); IntOGen driver in 1 cohort (MEL)","Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/qki/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}