{"entity":{"id":"quail-100","kind":"drug","name":"QUAIL-100","aka":[],"tldr":"QUAIL-100 is an experimental live bacterial therapy from Laguna Biotherapeutics, in phase 1 trials for acute leukaemia and myelodysplastic syndrome.","summary":"QUAIL-100 is a live bacterial therapy (attenuated) from Laguna Biotherapeutics. A live, attenuated bacterial therapeutic from Laguna's QUAIL platform, which uses highly attenuated microbes designed to activate and expand the body's own innate T cells. Its furthest stage is phase 1, for acute leukaemia and myelodysplastic syndrome. ClinicalTrials.gov registers it in one study linked below. First-in-human NCT07573111 recruiting (registry, checked 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Laguna Biotherapeutics: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT07573111"},{"label":"Laguna Biotherapeutics: lagunabio.com","url":"https://lagunabio.com/"},{"label":"ClinicalTrials.gov: trials of QUAIL-100","url":"https://clinicaltrials.gov/search?intr=QUAIL-100"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["all-leukemia","mds"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["laguna-biotherapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07573111"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"QUAIL-100","modality":"Live bacterial therapy (attenuated)","mechanism":"A live, attenuated bacterial therapeutic from Laguna's QUAIL platform, which uses highly attenuated microbes designed to activate and expand the body's own innate T cells.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/quail-100/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"company":[{"id":"laguna-biotherapeutics","kind":"company","name":"Laguna Biotherapeutics","route":"/companies/laguna-biotherapeutics/"}],"trial":[{"id":"nct07573111","kind":"trial","name":"Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation","route":"/trials/nct07573111/"}]}}