{"entity":{"id":"quest-hereditary-cancer-panel","kind":"drug","name":"Quest Comprehensive Hereditary Cancer Panel (66 genes)","aka":[],"tldr":"Quest Diagnostics' test of 66 genes linked to inherited cancer risk, ordered through a clinician.","summary":"Registered in the NIH Genetic Testing Registry as GTR000592394.4 (updated 25 June 2024) by Quest Diagnostics Nichols Institute San Juan Capistrano (CLIA 05D0643352), order code 38600: 66 genes, including the Fanconi genes FANCA, FANCC and FANCM, BLM, NTHL1, POLE, POLD1, FLCN, MET, PTCH1 and SUFU alongside the breast, ovarian and Lynch genes. GTR does not record a development type for this entry; it is not among the FDA-authorised hereditary cancer products.","status":"established","asOf":"2026-11-04","links":[{"label":"NIH Genetic Testing Registry GTR000592394.4","url":"https://www.ncbi.nlm.nih.gov/gtr/tests/592394/"},{"label":"NIH Genetic Testing Registry data file (test_version.gz)","url":"https://ftp.ncbi.nlm.nih.gov/pub/GTR/data/test_version.gz"}],"tags":["test","hereditary"],"related":[],"cancers":[],"sections":[],"technologies":["germline-testing"],"targets":["brca","palb2","mlh1","msh2","fanca","blm","nthl1","flcn","met"],"drugs":[],"companies":["quest-diagnostics"],"institutions":[],"pathways":[],"terms":["hereditary-cancer-syndromes","lynch-syndrome","nthl1-associated-polyposis","birt-hogg-dube-syndrome"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"Comprehensive Hereditary Cancer Panel","modality":"Germline hereditary cancer sequencing panel test","mechanism":"Next-generation sequencing of 66 hereditary cancer genes in germline DNA.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/quest-hereditary-cancer-panel/","neighbours":{"technology":[{"id":"germline-testing","kind":"technology","name":"Germline (hereditary) testing","route":"/technologies/germline-testing/"}],"target":[{"id":"blm","kind":"target","name":"BLM","route":"/targets/blm/"},{"id":"brca","kind":"target","name":"BRCA1 / BRCA2 (HRD)","route":"/targets/brca/"},{"id":"fanca","kind":"target","name":"FANCA","route":"/targets/fanca/"},{"id":"flcn","kind":"target","name":"FLCN","route":"/targets/flcn/"},{"id":"met","kind":"target","name":"MET","route":"/targets/met/"},{"id":"mlh1","kind":"target","name":"MLH1","route":"/targets/mlh1/"},{"id":"msh2","kind":"target","name":"MSH2","route":"/targets/msh2/"},{"id":"nthl1","kind":"target","name":"NTHL1","route":"/targets/nthl1/"},{"id":"palb2","kind":"target","name":"PALB2","route":"/targets/palb2/"}],"company":[{"id":"quest-diagnostics","kind":"company","name":"Quest Diagnostics","route":"/companies/quest-diagnostics/"}],"term":[{"id":"birt-hogg-dube-syndrome","kind":"term","name":"Birt-Hogg-Dubé syndrome","route":"/terms/birt-hogg-dube-syndrome/"},{"id":"hereditary-cancer-syndromes","kind":"term","name":"Hereditary cancer syndromes","route":"/terms/hereditary-cancer-syndromes/"},{"id":"lynch-syndrome","kind":"term","name":"Lynch syndrome","route":"/terms/lynch-syndrome/"},{"id":"nthl1-associated-polyposis","kind":"term","name":"NTHL1-associated polyposis","route":"/terms/nthl1-associated-polyposis/"}]}}