{"entity":{"id":"rad51","kind":"target","name":"RAD51","aka":["RAD51 recombinase","DNA repair protein RAD51 homolog 1","HsRad51","HsT16930","BRCC5","FANCR","RAD51A"],"tldr":"RAD51 (DNA repair protein RAD51 homolog 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Homologous DNA recombinase that catalyses strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.61, affected pathway 0.87, literature 0.99, genetic association 0.70, somatic mutation 0.49).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9817","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9817"},{"label":"UniProt Q06609","url":"https://www.uniprot.org/uniprotkb/Q06609/entry"},{"label":"NCBI Gene 5888","url":"https://www.ncbi.nlm.nih.gov/gene/5888"},{"label":"Ensembl ENSG00000051180","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000051180"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["homologous-recombination-repair"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RAD51","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9817","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9817","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q06609","url":"https://www.uniprot.org/uniprotkb/Q06609/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000051180","url":"https://platform.opentargets.org/target/ENSG00000051180/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: breast cancer 0.64 (GraphQL API, CC0)"}],"hgnc":"HGNC:9817","ensembl":"ENSG00000051180","uniprot":"Q06609","entrez":"5888","biology":"Homologous DNA recombinase that catalyses strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilisation of RAD51-ssDNA filaments by blocking ATP hydrolysis. Nucleosomal DNA is peeled from the histone surface by the RAD51 filament. Recruited to resolve stalled replication forks during replication stress. Location: Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 15q15.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rad51/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"pathway":[{"id":"homologous-recombination-repair","kind":"pathway","name":"Double-strand break repair: HR versus end joining","route":"/pathways/homologous-recombination-repair/"}]}}