{"entity":{"id":"rad54l","kind":"target","name":"RAD54L","aka":["RAD54 like","DNA repair and recombination protein RAD54-like","hHR54","hRAD54","RAD54A"],"tldr":"RAD54L (DNA repair and recombination protein RAD54-like) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognised.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Olaparib. Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.91, animal model 0.55, genetic association 0.76, somatic mutation 0.55).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9826","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9826"},{"label":"UniProt Q92698","url":"https://www.uniprot.org/uniprotkb/Q92698/entry"},{"label":"NCBI Gene 8438","url":"https://www.ncbi.nlm.nih.gov/gene/8438"},{"label":"Ensembl ENSG00000085999","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085999"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RAD54L","role":["drug-target","biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:9826","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9826","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92698","url":"https://www.uniprot.org/uniprotkb/Q92698/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RAD54L","url":"https://civicdb.org/features/6676","note":"1 evidence items, 0 assertions, 1 variants; diseases: Castration-resistant Prostate Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000085999","url":"https://platform.opentargets.org/target/ENSG00000085999/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9826","ensembl":"ENSG00000085999","uniprot":"Q92698","entrez":"8438","biology":"Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognised. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Location: Nucleus (UniProt). Locus 1p34.1 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rad54l/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}