{"entity":{"id":"radcomp","kind":"trial","name":"RADCOMP","aka":[],"tldr":"A randomised trial of protons versus photons for non-metastatic breast cancer, asking whether protons spare the heart and lung when the breast and nodes need radiation.","summary":"RADCOMP (NCT02603341) randomises non-metastatic breast cancer to proton or photon radiotherapy, with major cardiovascular events as a long-horizon endpoint. The anatomy (left chest wall, internal mammary nodes, heart, lung) is where exit dose and a distal Bragg peak could matter. It tests integral dose and whether variable RBE at the chest-wall/heart interface helps or hurts. ClinicalTrials.gov listed the study as active, not recruiting, with primary completion estimated in 2036; no primary readout is in the corpus.","status":"active","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT02603341","url":"https://clinicaltrials.gov/study/NCT02603341"}],"tags":["radiation-wave5"],"related":[],"cancers":["breast-hr-positive","breast-her2-positive","tnbc"],"sections":[],"technologies":["proton-therapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["relative-biological-effectiveness","linear-energy-transfer","bragg-peak"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT02603341","phase":"3","setting":"Non-metastatic breast cancer: proton versus photon radiotherapy","sponsor":"Abramson Cancer Center at Penn Medicine","outcomes":[]},"route":"/trials/radcomp/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"term":[{"id":"bragg-peak","kind":"term","name":"Bragg peak","route":"/terms/bragg-peak/"},{"id":"linear-energy-transfer","kind":"term","name":"Linear energy transfer (LET)","route":"/terms/linear-energy-transfer/"},{"id":"relative-biological-effectiveness","kind":"term","name":"Relative biological effectiveness (RBE)","route":"/terms/relative-biological-effectiveness/"}],"pairing":[{"id":"proton-vs-imrt","kind":"pairing","name":"Caution: proton therapy vs IMRT","route":"/pairings/proton-vs-imrt/"}],"idea":[{"id":"idea-fund-proton-coverage-with-evidence","kind":"idea","name":"Pooled coverage-with-evidence for proton therapy across all centres","route":"/ideas/idea-fund-proton-coverage-with-evidence/"},{"id":"idea-bio2-let-rbe-ab-selects-protons","kind":"idea","name":"Use LET, RBE and alpha/beta to decide when protons beat IMRT","route":"/ideas/idea-bio2-let-rbe-ab-selects-protons/"}]}}