{"entity":{"id":"radiation-necrosis","kind":"term","name":"Radiation necrosis (brain)","aka":[],"tldr":"Death of brain tissue months to years after radiosurgery or high-dose brain radiotherapy, which can look exactly like tumour growing back on a scan.","summary":"Radiation necrosis affects a minority of patients after stereotactic radiosurgery to brain metastases and after high-dose treatment of gliomas, more often with larger volumes and with concurrent immunotherapy or targeted drugs. It causes swelling and symptoms that mimic progression; perfusion MRI, amino-acid PET and sometimes biopsy separate the two. Treatment is steroids, bevacizumab for refractory cases, and occasionally surgery or laser ablation.","asOf":"2026-09-16","wikipedia":"https://en.wikipedia.org/wiki/Radiation_necrosis","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Radiation_necrosis"}],"tags":["radiation-wave1"],"related":[],"cancers":["brain-tumours","glioblastoma","metastatic-cancer"],"sections":[],"technologies":["radiosurgery-srs","mri"],"targets":[],"drugs":["bevacizumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"category":"Side effects"},"route":"/terms/radiation-necrosis/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"technology":[{"id":"mri","kind":"technology","name":"MRI","route":"/technologies/mri/"},{"id":"radiosurgery-srs","kind":"technology","name":"Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)","route":"/technologies/radiosurgery-srs/"}],"drug":[{"id":"bevacizumab","kind":"drug","name":"Bevacizumab","route":"/drugs/bevacizumab/"}]}}